Effect of Hyperuricaemia on Perinatal Outcome in Preeclampsia

Pages: 339-343
Sumitra Thapa and Anuja Joshi (Armed Police Hospital, Balambu, Kathmandu, Nepal)

Pre-eclampsia and eclampsia are among the commonest medical disorders causing morbidity and mortality during pregnancy. In preeclampsia raised uric acid concentration takes place after decreased uric acid clearance. It is assumed that hyperuricaemia is an indication of renal cortical blood flow dysfunction which parallels the decreased perfusion of placenta. Rise in serum uric acid is frequently earlier than any other renal parameter. A prospective hospital based cross sectional comparative study was carried out in Tribhuvan University Teaching Hospital from 14th April 2019-13th April 2020. Hundred pregnant women diagnosed as pre-eclampsia were enrolled for the study. Based on serum uric acid level the pre-eclampsia patients were divided into 2 groups. Group A (n=47) with serum uric acid level < 5.5 mg% and Group B (n=53) ≥ 5.5mg%. Perinatal outcome was compared in both groups. Prevalence of pre-eclampsia was 2.63% among which 29 cases were severe and 71 were mild pre-eclampsia. The prevalence of hyperuricaemia in pre-eclampsia patients was 53% and hyperuricaemia was found significantly more in severe pre-eclampsia. Pre-eclampsia was commonly seen in the age group of 21- 25 years (38%) and more in primigravida (58%). Overall prevalence of pre-eclampsia was 2.63% and prevalence of hyperuricaemia was 53% in pre-eclampsia. Adverse perinatal outcome was more in hyperuricaemic group. Thus serum uric acid level serves to identify the severity of pre-eclampsia and increasing level suggests the risk of developing worse adverse perinatal outcome