Impact of Obesity on Live Birth among Women Undergoing IVF/ICSI: A Meta-Analysis

Pages: 344-353
Sarthak Gulati1, Dimple Rawat2, Shreya Gulati3, Rinchen Zangmo4, Arti Gulati5, Mahesh Kumar Seth6
Aradhana Kumari7, and Amit Kumar8 (Department of Orthopedics, J.J.M Medical College, Davanagere, Karnataka1, Clinical Epidemiology Unit, All India Institute of Medical Sciences, New Delhi2,5,6,7, Dr. Ram Manohar Lohia Hospital, New Delhi3, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi4, and Department of Neurology, All India Institute of Medical Sciences, New Delhi8)

In the past few decades a worldwide increase is observed in obesity prevalence among women of reproductive age group which may be linked with poor repriductive health outcomes moreover there is contradictory evidence about the effect of obesity on the live-birth following assisted reproducitve technology. To determine the pooled estimate of the association of female obesity with the probability of live birth outcome following in-vitro fertilzation/itractoplasmic sperm injection (IVF/ICSI). To evaluate the pooled effect of BMI on live birth as outcome following IVF/ICSI we carried this review. Platform PubMed, Google Scholar, Cochrane libraray and clinicaltrial.gov were used for literature searching since inception till March, 2020 to identify all the relevant studies. Differences in live births among underweight, normal weight, and overweight women incomparison to the obese group (BMI >30) were determined. For heterogenity >50% raandom-effects otherwise fixed-effects model was used to determine the pooled Risk ratio with 95% CI or pooled Odds Ratio with CI. Joanna Briggs Institute checklist (JBI) was used for methodological quality of the studies. Software STATA version 13, was used to conduct the statistical analysis p-value <0.05 was considered as degree of siginificant association. In the present meta-analysis thirty-two studies were included. Our finding suggests that women with obesity had 26% less live births as compared to women with normal BMI (OR, 0.74, 95% CI 0.69 to 0.78), 17% less live births compared to women with underweight (OR 0.83, 95% CI 0.80 to 0.85) and 14% less live births as compared to women with overweight (OR 0.86, 95% CI 0.83 to 0.88). The findings of present updated meta-analysis precisely demonstrated that female obesity is negatively associated with live birth rate following IVF/ICSI.