Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in Dentistry: A Review

Description

Page: 109-112

Anjana Goyal¹, Reena Doomra², Ankita Bhardwaj³, Jasmine Sindhoo⁴, Satakshi⁵, Alishba Zainab Khan^6, Adnan⁷, and Manish Kumar⁸ (Department of Biochemistry, Manav Rachna Dental College, MRIIRS, Faridabad, Haryana¹, Department of Pharmacology, Manav Rachna Dental College, MRIIRS, Faridabad, Haryana², and Manav Rachna Dental College, MRIIRS, Faridabad, Haryana³,⁴,⁵,⁶,⁷,⁸)

The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), a gene-editing technology derived from prokaryotes, is transforming the landscape of biomedical research (Garcia-Robledo et al., 2020). The ability to modulate gene expression, correct genomic errors, and eradicate foreign DNA segments has opened up new possibilities for treating systemic disorders. Scientists are utilizing CRISPR to create human cell lines and develop novel treatments. Its potential extends beyond the laboratory, with promising applications in dentistry, oncology, genetic and infectious diseases, agriculture and biotechnology. As researchers continue the research on CRISPR and address ethical concerns, this groundbreaking discovery has great therapeutic potential in research and medicine. CRISPR-Cas have been used for targeted therapies in bacteriophages (Zhang et al., 2022). CRISPR can modify cancer-related genes, thereby help to develop novel treatment options that could potentially disrupt tumour growth and improve patient outcomes. Additionally, CRISPR is being explored as a tool to correct genetic disorders by editing disease-causing mutations. Furthermore, CRISPR’s ability to target specific DNA sequences, ways to target and eliminate pathogenic DNA sequences, potentially offering better therapeutic approaches against bacterial infections. These advancements in CRISPR technology hold great potential for transforming the field of research and opening up new possibilities in various dental conditions such as dental caries, dental plaque and oral cancer.